Cell cycle models for molecular biology and molecular oncology: Exploring new dimensions

Cytometry ◽  
1999 ◽  
Vol 35 (2) ◽  
pp. 97-116 ◽  
Author(s):  
Stanley E. Shackney ◽  
T. Vincent Shankey
1995 ◽  
Vol 112 (5) ◽  
pp. P88-P89
Author(s):  
Norris K. Lee

Educational objectives: To understand basic molecular biological concepts and breakthroughs as they apply to the head and neck cancer model and to envision the future of head and neck cancer treatment, within the context of molecular biology.


Nature ◽  
1981 ◽  
Vol 293 (5834) ◽  
pp. 648-650 ◽  
Author(s):  
J. A. Smith ◽  
D. J. R. Laurence ◽  
P. S. Rudland

1994 ◽  
Vol 27 (1) ◽  
pp. 421-422
Author(s):  
Lorenzo Cazzador ◽  
Luigi Mariani

1988 ◽  
Vol 131 (2) ◽  
pp. 255-262 ◽  
Author(s):  
Gilles Hejblum ◽  
Dominique Costagliola ◽  
Alain-Jacques Valleron ◽  
Jean-Yves Mary
Keyword(s):  

2001 ◽  
Vol 213 (1) ◽  
pp. 89-101 ◽  
Author(s):  
JOANNA TYRCHA

2016 ◽  
Author(s):  
Kati Böhm ◽  
Fabian Meyer ◽  
Agata Rhomberg ◽  
Jörn Kalinowski ◽  
Catriona Donovan ◽  
...  

AbstractBacteria regulate chromosome replication and segregation tightly with cell division to ensure faithful segregation of DNA to daughter generations. The underlying mechanisms have been addressed in several model species. It became apparent that bacteria have evolved quite different strategies to regulate DNA segregation and chromosomal organization. We have investigated here how the actinobacteriumCorynebacterium glutamicumorganizes chromosome segregation and DNA replication. Unexpectedly, we find thatC. glutamicumcells are at least diploid under all conditions tested and that these organisms have overlapping C-periods during replication with both origins initiating replication simultaneously. Based on experimentally obtained data we propose growth rate dependent cell cycle models forC. glutamicum.


2018 ◽  
Vol 22 ◽  
pp. 363-367
Author(s):  
H. B. Humeniuk ◽  
M. Z. Mosula ◽  
I. B. Chen ◽  
N. M. Drobyk

The scientific and organizational activities of the worldwide known scientist in the field of molecular biology James Dewey Watson were described in this article. 55 years ago James Watson and Francis Crick made one of the key discoveries of the twentieth century. They have found that DNA has a double helix structure. This discovery was based on the X-rays patterns obtained by Maurice Wilkson and Rosalind Franklin. Subsequently, this DNA model had been proved, and J. Watson and F. Crick were awarded with the Nobel Prize in Physiology or Medicine in 1962. Since, our knowledge of the main molecule of life has been greatly expanded. A significant flowering of molecular genetics has began: synthesis of RNA and DNA in vitro, decoding of genetic code, recombinant DNA technology, genetic engineering, sequencing of genomes and post genomic technologies. James Watson is one of the authors of the cell biology classic textbook “Molecular Biology of the Cell”. In addition, he has developed the current areas of molecular biology such as  molecular oncology and molecular neurobiology. Today genomes of different animals and humans have been decoded and the functions of many genes have been determined. But at present still unknown how the DNA starts and how it affects the work of the organs and the organism as a system. Keywords: James Watson, DNA structure, Nobel Prize in physiology or medicine, Molecular Biology of the Cell.


2001 ◽  
Vol 38 (03) ◽  
pp. 685-695 ◽  
Author(s):  
Marina Alexandersson

We use multi-type branching process theory to construct a cell population model, general enough to include a large class of such models, and we use an abstract version of the Perron-Frobenius theorem to prove the existence of the stable birth-type distribution. The generality of the model implies that a stable birth-size distribution exists in most size-structured cell cycle models. By adding the assumption of a critical size that each cell has to pass before division, called the nonoverlapping case, we get an explicit analytical expression for the stable birth-type distribution.


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